William A. Leone, MD, FACS is one of the nation’s top orthopedic surgeons who has built his practice at Holy Cross Health. A recognized expert in his field, he has operated on thousands of people with hip and knee conditions from all over the world. He prides himself on solving complex hip and knee problems and is gratified by the profound positive effect that his interventions have had on the lives of his patients.
Dr. Leone founded The Leone Center in 2009 in order to provide state-of-the-art orthopedic care, using proven techniques and technologies in a compassionate, patient-focused way. He uses a range of technologies in his practice, including computer navigation, kinematic sensors and robotics for partial and total knee replacements, and his own invention, the Pelvic Alignment Level (PAL), for implant positioning, balancing and leg length reconstruction during total hip replacements. His meticulous, precise and gentle soft-tissue handling during surgery results in less tissue trauma, bleeding and postoperative pain. This approach consistently produces faster healing and better outcomes.
A sought-after industry consultant for implant, instrument design and clinical application for the orthopedic industry, Dr. Leone has been involved in clinical trials and reviews of new orthopedic techniques and equipment. He has taken an active role as chairperson and faculty at symposiums that provide continuing medical education for hip and knee surgeons in the United States, Europe, Latin America and the Caribbean. In addition to lectures, he mentors orthopedic surgeons as well joint replacement fellows and medical and pre-medical students in patient care and surgical techniques.
Diagnosis and treatment of complex hip and knee problems
Hip Replacement Surgery
Minimally invasive total hip replacement
Revision total hip replacement
Complex hip and femoral reconstruction
Knee Replacement Surgery
Minimally invasive computer assisted total knee replacement
Robotic/computer-assisted partial and total knee replacement
Revision total knee
Certifications and Licensure
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American Board of Orthopedic Surgery
State of Florida Medical License
Certified surgeon in computer-assisted knee replacement surgery
Certified surgeon in robotic-assisted partial and total knee replacement surgery (MAKOplasty)
MD, Emory University School of Medicine, Atlanta, Georgia
BA, Magna Cum Laude, University of South Florida, Tampa, FL
Fellowship, Joint Reconstructive Surgery with Gordon E. Hill, MD, Holy Cross Hospital, Ft. Lauderdale, FL
Residency, Orthopedic Surgery, University of Miami, Miami, Florida; Resident of the Year
Internship, General Surgery, University of Miami, Miami, Florida
Honors & Awards
Diplomat, American Board of Orthopedic Surgery
Fellow, American Academy of Orthopedic Surgeons
Fellow, American College of Surgeons
Florida Top Orthopedic Surgeon, 2010-2023, Castle Connolly Medical Ltd.
Top docs of 2023, Boca Raton Observer
South Florida Top Doctor, 2010-2023, Fort Lauderdale Illustrated Magazine ( formerly Gold Coast Magazine)
The “Best Doctor” award Fort Lauderdale Magazine August 2022 and August 2023
Doctor of the Year, 2000, Arthritis Foundation’s
Former Chair of Holy Cross Hospital Department of Orthopedics
Professional Associations & Affiliations
Member, American Medical Association
Member, American Association of Hip and Knee Surgeons
Member, Association of American Physicians and Surgeons
Member, Southeast Orthopedic Society
Member, Florida Medical Association
Member, Florida Orthopedic Society
Member, Broward County Medical Association
Member, Broward County Orthopedic Society
Inventor of the Pelvic Alignment Level (PAL), a device and technique that assists surgeons during Total Hip Replacement (THR) to achieve more precise implant positioning and leg length, to optimize hip mechanics and to maximize longevity of the prosthetic joint.
A New Surgical Instrument and Technique designed to Achieve More Accurate Component Placement in Total Hip Replacement. Techniques in Orthopaedics, 2011
The Effect of Preoperative Planning and Impaction Grafting Surgical Technique on Intraoperative and Postoperative Complication Rate for Femoral Revision Patients with Moderate to Severe Bone Loss: Mean 4.7-Year Results, The Journal of Arthroplasty, November 26, 2007.
Technique on Intraoperative and Postoperative Complication Rate for Femoral Revision Patients with Moderate to Severe Bone Loss: Mean 4.7-Year Results, The Journal of Arthroplasty November 26, 2007.
The Sequential Effects of Ligament Releases to Soft Tissue Tension in a Valgus Total Knee Replacement, AAHKS Annual Meeting, November 2016, Poster #20
Using Sensors to Evaluate Total Knee Replacement: Treating the Looks Good but Feels Bad Knee, Ecronicon, July 2016
How we are addressing ligament balance in Total Knee Replacement? A literature review revision etiology and technological advancement, Journal of Clinical Orthopaedics and Trauma, 2016
Early Outcomes of Revision Surgery for Taper Corrosion of Dual Taper Total Hip Replacement with Pseudotumors in 187 Patients, AAOS Paper, 2016
A Systematic Literature Review of Three Modalities in Technologically Assisted Total Knee Replacement, Leone et. al, Advances in Orthopedics, 2015
Do Metal Levels Normalize Following Revision Surgery for Pseudotumor in Patients with Dual Taper Modular Total Hip Replacement? AAOS Paper, 2015
Maximizing Clinical Outcomes after Revision and Primary Total Knee Arthroplasty Using Intraoperative Sensors, AAOS Scientific Exhibit, 2015
Utility of Serum and Synovial Fluid in Diagnosis of Infection in Patients with Corrosion of Dual Taper Modular Stem AAOS Poster, 2015
Using Intraoperative Sensor Technology to Guide Revision in the Chronically Painful Knee: A Two-Patient Case Study, Ecronicon, 2015
What is the Prevalence of PseudoTumors in Total Hip Arthroplasty Patients with Dual Taper Modular Femoral Stem? AAOS Paper, 2014
Metal Ion Level in Patients with Dual Taper Modular Total Hip Replacement: Sensitivity and Specificity for Predicting “Pseudotumors”, AAOS poster 2014